Project Team

KAREN PHILLIPS, PHD

Karen Phillips, Assistant Professor, Faculty of Health Sciences, University of Ottawa. Dr. Phillips has an extensive background in reproductive physiology, oocyte maturation, molecular mechanisms controlling fertilization and preimplantation embryo development. Dr. Phillips also has experience in clinical embryology and the treatment of infertility through assisted reproductive technologies.

Selected Publications:

Phillips KP, Petrunewich MA, Collins JL, Baltz JM. The intracellular pH-regulatory HCO3-/Cl- exchanger in the mouse oocyte is inactivated during first meiotic metaphase and reactivated after egg activation via the MAP kinase pathway. Mol. Biol. Cell. 2002; 13(11): 3800-3810.

Phillips KP, Petrunewich MA, Collins JL, Booth RA, Liu XJ, Baltz JM. Inhibition of MEK or cdc2 kinase parthenogenetically activates mouse eggs and yields the same phenotypes as mos-/- parthenogenotes. Dev. Biol. Dev Biol. 2002; 247(1):210-23.

Steeves CL, Lane M, Bavister BD, Phillips KP, Baltz JM. Intracellular pH regulation in mouse 2-cell embryos by the Na+/H+ antiporter. Biol. Reprod. 2001; 65(1):14 22.

Phillips KP, Leveille MC, Claman P, Baltz JM. Intracellular pH regulation in human preimplantation embryos. Hum. Reprod. 2000; 15(4):896 904.

Phillips KP, Baltz JM. Intracellular pH regulation by HCO3-/Cl- exchange is activated during early mouse zygote development. Dev. Biol. 1999; 208:392-405.

Baltz JM, Phillips KP. Intracellular ion measurements in single eggs and embryos using ion-sensitive fluorophores. In: Advances in Molecular Biology: A Comparative Methods Approach to the Study of Oocytes and Embryos (ed. JD Richter). Oxford University Press, Oxford. p.39-82. 1999.

Phillips KP, Zhou, W, Baltz JM. Are intracellularly-loaded ion-sensitive fluorophores toxic to mouse eggs and zygotes? Zygote. 1998; 6:113-123.

Phillips KP, Baltz JM. An intracellular pH change does not accompany egg activation in the mouse. Mol. Reprod. Dev. 1996; 45:52-60.