Équipe du projet

KAREN PHILLIPS, PH. D.

Karen Phillips est professeur agrégé, faculté de médecine, Université d'Ottawa. Elle possède une vaste connaissance de la physiologie de la reproduction, de la maturation des ovocytes et des mécanismes moléculaires qui contrôlent la fécondation et le développement de l'embryon avant son implantation, ainsi qu'une expérience de l'embryologie clinique et du traitement de la stérilité par les techniques de reproduction assistée.

Publications choisies

Phillips KP, Petrunewich MA, Collins JL, Baltz JM. The intracellular pH-regulatory HCO3-/Cl- exchanger in the mouse oocyte is inactivated during first meiotic metaphase and reactivated after egg activation via the MAP kinase pathway. Mol. Biol. Cell. 2002; 13(11): 3800-3810.

Phillips KP, Petrunewich MA, Collins JL, Booth RA, Liu XJ, Baltz JM. Inhibition of MEK or cdc2 kinase parthenogenetically activates mouse eggs and yields the same phenotypes as mos-/- parthenogenotes. Dev. Biol. Dev Biol. 2002; 247(1):210-23.

Steeves CL, Lane M, Bavister BD, Phillips KP, Baltz JM. Intracellular pH regulation in mouse 2-cell embryos by the Na+/H+ antiporter. Biol. Reprod. 2001; 65(1):14 22.

Phillips KP, Leveille MC, Claman P, Baltz JM. Intracellular pH regulation in human preimplantation embryos. Hum. Reprod. 2000; 15(4):896 904.

Phillips KP, Baltz JM. Intracellular pH regulation by HCO3-/Cl- exchange is activated during early mouse zygote development. Dev. Biol. 1999; 208:392-405.

Baltz JM, Phillips KP. Intracellular ion measurements in single eggs and embryos using ion-sensitive fluorophores. In: Advances in Molecular Biology: A Comparative Methods Approach to the Study of Oocytes and Embryos (ed. JD Richter). Oxford University Press, Oxford. p.39-82. 1999.

Phillips KP, Zhou, W, Baltz JM. Are intracellularly-loaded ion-sensitive fluorophores toxic to mouse eggs and zygotes? Zygote. 1998; 6:113-123.

Phillips KP, Baltz JM. An intracellular pH change does not accompany egg activation in the mouse. Mol. Reprod. Dev. 1996; 45:52-60.