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Subject: EM-COM
Question: I am a student in the Environmental Sciences Program at UBC and we are currently putting together mock research proposals. I have decided to focus on determining the Endocrine Disrupter content of Vancouver sewage water and the prevalence in the local coastal ecosystems. I was wondering if you could direct me to some information about detection methods for Endocrine Receptors, to a list of identified Endocrine Receptors or any other information you think is relevant to my project. Thanks for your time,|
Meaghan

Answer:Thanks for your question Meaghan,

Critical references include:

• The 2002 WHO report on Global Assessment of the State of the Science http://www.who.int/pcs/emerg_site/edc/global_edc_TOC.htm
  
  
• Second National Report on Human Exposure to Environmental Chemicals. 2003 CDC http://www.cdc.gov/exposurereport/
  
  
• Characterizing the effects of endocrine disruptors on human health at environmental exposure levels. Raleigh, North Carolina, May 1998
  
  
• The National Institute of Environmental Health Sciences, U.S. Environmental Protection Agency (EPA), U.S Food and Drug Administration/National Center for Toxicological Research and the Chemical Manufacturers Association
  
  
• Introduction-Workshop on characterizing the effects of endocrine disruptors on human health at environmental exposure levels. Melnick, Ronald L. Environmental Health Perspectives 107 Suppl 4:603-604. 1999. Summary PM:10421769
  
  
• An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults. Nira Ben-Jonathan, Ralph L. Cooper, Paul Foster, Claude L. Hughes, Patricia B. Hoyer, Diane Klotz, Michael Kohn, Dolores J. Lamb, George M. Stancel. Environmental Health Perspectives 107(Suppl 4):605-611. 1999. Summary PM:10421770
  
  
• Evaluating the effects of endocrine disruptors on endocrine function during development. Bigsby R, Chapin RE, Daston GP, Davis BJ, Gorski J, Gray LE, Howdeshell KL, Zoeller RT, vom Saal FS. Environmental Health Perspectives 107 Suppl 4:613-8. 1999. Summary PM:10421771
  
  
• Species, interindividual, and tissue specificity in endocrine signalling. Cheryl Walker, S. Ansar Ahmed, Terry Brown, Shuk-Mei Ho, Leslie Hodges, George Lucier, Jose Russo, Nancy Weigel, Tom Weise, John Vandenbergh. Environmental Health Perspectives 107(Suppl 4):619-624. 1999. Summary PM:10421772
  
  
• Quantitative mechanistically based dose-response modelling with endocrine-active compounds. Andersen ME, Conolly RB, Faustman EM, Kavlock RJ, Portier CJ, Sheehan DM, Wier PJ, Ziese L. Environmental Health Perspectives 107 Suppl 4:631-8 1999. Summary PM:10421774
  
  
• New approaches for estimating risk from exposure to diethylstilbestrol. Cunha GR, Forsberg JG, Golden R, Haney A, Iguchi T, Newbold R, Swan S, Welshons W. Environmental Health Perspectives 107 Suppl 4:625-30. 1999. Summary PM:10421773
  
  
• Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. Brouwer A, Longnecker MP, Birnbaum LS, Cogliano J, Kostyniak P, Moore J, Schantz S, Winneke G. Environmental Health Perspectives 107 Suppl 4:639-49. 1999. Summary PM:10421775

All of these are summarized on the EM-COM website (http://www.emcom.ca/science/work_rep.shtml), but perhaps you should go through each reference to find material most relevant for your project.