Featured Questions, Comments and Responses

Subject: EM-COM Queries
Question: I have a question don't really know if it relates to this study in any way, but I want to know what are the chemical process and changes that occur when estrogen is burned?
Rhaeyn

Answer: Thank you for your question. The three primary estrogens are Estrone (E1), Estradiol (E2), and Estriol (E3). Metabolism of these hormones produces the catechol estrogens such as 2-Hydroxy Estrone (2OHE1) & 4-Hydroxy Estrone (4OHE1) and their methyl metabolites, 2-Methoxy Estrone (2MeOHE1) and 4-Methoxy Estrone (4MeOHE1).
E1 is formed from the metabolism of androstenedione (AD) through a P450 aromatase. E2 is derived from testosterone via a P450 aromatase enzyme or conversion of E1 through a 17-beta Hydroxysteroid Dehydrogenase enzyme. E3 is developed from the conversion of E1 to 16-alpha Hydroxy Estrone (16aOHE1) to E3.

The melting point of estradiol is 173 C, with a change of state from solid to liquid occurring at that temperature. Generally, estrogen is considered physically inert.